A prolonged Delta SARS-CoV-2 infection during the Omicron wave in an HIV immunosuppressed patient
Year: 2025
Type: article
Study design: Case Report
Abstract: Here, we describe a fatal, prolonged Delta SARS-CoV-2 infection lasting 55 days during the Omicron wave in a severely immunosuppressed HIV patient. We observed persistent viral replication, high within-host mutation rates, and emergence of rare spike mutations. Findings suggest prolonged infections may drive SARS-CoV-2 evolution and reintroduce variants presumed extinct into immune-evasive forms.
Authors: Diego García-Martínez de Artola, Laura Ciuffreda, Jose Miguel Lorenzo-Salazar, Adrián Muñoz-Barrera, Rafaela González-Montelongo, Nora Rodríguez-García, Julia Alcoba-Florez, Lucy Abella-Vazquez, Santiago Melón, Carlos Flores
Institutions: Hospital Universitario Nuestra Señora de Candelaria, Instituto Tecnológico y de Energías Renovables, Universidad de Oviedo, Hospital Universitario Central de Asturias, Instituto de Salud Carlos III, Universidad Fernando Pessoa Canarias, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,900
Awards: G1611690528, Evaluación funcional de variantes asociadas y análisis genómicos complementarios para identificar genes implicados en el síndrome de distrés respiratorio agudo, G290987901, G3024053206, G3420861723, G4348583464, G4456448350, G4775530708, G4965254727, G55607902, G6039394674, G6441789154, G7627102896, G917718799
OpenAlex ID: W4416424809