Vancomycin-specific Urinary Immunostaining for Noninvasive Screening of Vancomycin-associated Cast Nephropathy
Year: 2025
Type: article
Abstract: Vancomycin is a widely used antibiotic and a known cause of acute kidney injury (V-AKI). Recent studies suggest that vancomycin can form obstructive aggregates with uromodulin in kidney tubules, contributing to acute kidney injury (V-AKI). However, detecting these aggregates typically requires kidney tissue for immunostaining. Urine-based vancomycin immunostaining has been proposed as a non-invasive alternative for diagnosing V-AKI, but its specificity remains uncertain.
Source: Kidney Medicine
Institutions: Assistance Publique – Hôpitaux de Paris, Hôpital Tenon, Inserm, Sorbonne Université, Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée, Université Paris Cité, Génomes, biologie cellulaire et thérapeutiques, Hôpital Saint-Louis, Institut de recherche Saint-Louis, Université Sorbonne Paris Nord, Hôpital Avicenne
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
OpenAlex ID: W4416426243