Work

CD276-directed supramolecular nanoplatform with pH-triggered gemcitabine release for potent tumor stromal and vascular suppression

Year: 2025

Type: article

Abstract: sustained circulation and targeted delivery. By specifically targeting CD276, this platform minimizes systemic toxicity and potentially improving patient tolerability, offering promising prospects for clinical translation and better outcomes in pancreatic cancer treatment.

Source: International Journal of Pharmaceutics X

DOI: 10.1016/j.ijpx.2025.100452

Authors: Jiayi Li, Hao Liu, Zhijun Li, Zhihuan Zheng, Lanzhu Luo, Liqing Lin, Jizhen Lin, Gang Liu, Xinhua Lin, Bing Chen

Institutions: Fujian Medical University, Education Department of Fujian Province, Union Hospital, Fuzhou Neuro Psychiatric Hospital, Xiamen University, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590

Funders: National Natural Science Foundation of China, Natural Science Foundation of Fujian Province, Major State Basic Research Development Program of China

Awards: G1323634168, G1671386798, G2384968920, 智能仿生线粒体靶向递药系统的构建及其增强肝癌介入综合治疗的机制研究, G8710138999

OpenAlex ID: W4416426483

FWCI:

Cites: 34

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