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Acute Necrotizing Pancreatitis Secondary to Acute Intermittent Porphyria: A Rare Clinical Association

Year: 2025

Type: article

Abstract: We report a rare case of acute necrotizing pancreatitis in a 23-year-old man during an acute attack of acute intermittent porphyria (AIP). Initially presenting with neurovisceral symptoms and hyponatremia, he was diagnosed with AIP based on clinical features and a positive urine porphobilinogen test. Despite symptomatic improvement, he developed severe abdominal pain and elevated pancreatic enzymes, with imaging confirming necrotizing pancreatitis. He required prolonged supportive care, percutaneous drainage, and nutritional support. This case highlights the importance of recognizing pancreatic complications in AIP, as timely diagnosis and multidisciplinary management are crucial for favorable outcomes in this rare but serious association.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000001910

Authors: Sachin Wali, Wg Cdr Gaurav Pandey, Shreyas Gutte, Varunvenkat M. Srinivasan, Mohan Gurjar

Institutions: Sanjay Gandhi Post Graduate Institute of Medical Sciences, Command Hospital Air Force

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4416426949

FWCI:

Cites: 13

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