Work

Echocardiographic imaging in conscious, unsedated sheep: a novel approach enabling apical views for advanced cardiac assessment

Year: 2025

Type: article

Abstract: We establish the first protocol for high-fidelity echocardiography in conscious sheep, overcoming the long-standing barrier of apical view acquisition. This enables advanced indices, including volumetric ejection fraction and tissue Doppler, and provides reproducible reference values. Applied to a tachypacing model, it revealed progressive biventricular and atrial remodeling and an early therapeutic window, offering a powerful and clinically relevant platform for translational heart failure research.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00703.2025

Authors: Mohammed Obeidat, Agnieszka Swiderska-Cowen, Katharine M. Dibb, Luigi Venetucci, David Eisner, Andrew W. Trafford

Institution: University of Manchester

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: British Heart Foundation