Work

When rehabilitation is not enough, how targeting metabolism can overcome the limited plasticity of skeletal muscle after traumatic injury

Year: 2025

Type: article

Abstract: There is a category of large-scale neuromusculoskeletal injuries that result in long-term functional disabilities, and one such injury is volumetric muscle loss (VML) injury. In addition to the clinical outcomes related to long-term dysfunction, co-morbidities and reduced mobility and physical activity, this review addresses several underexplored physiological limitations of VML at both the whole-body level and within the injured muscle. Our objectives with this review are to provide: (1) critical understanding of the pathophysiological limitations related to VML injury; (2) evidence for emerging treatment options that target the VML-induced metabolic dysregulation; and (3) early functional data on metabolic treatments as a component of regenerative rehabilitation. We highlight new attempts to intervene in this unique pathophysiology, in addition to current unanswered questions for the field.

Source: Experimental Physiology

DOI: 10.1113/ep093074

Authors: Sarah M. Greising, Jarrod A. Call

Institutions: University of Minnesota, University of Georgia

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,940