Work

Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01902

Authors: Yunyuan Huang, Yanxi Li, Xin Chen, Huiling Wang, Qian Wang, Siying Liu, Yigui Li, Zhuo Chen, Jun Ma, Zeyue Huang, Jian Wan, Yanliang Ren, Jinrong Min

Institutions: Central China Normal University, Jinan University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Ministry of Education of the People's Republic of China, China Postdoctoral Science Foundation, National Key Research and Development Program of China

Awards: G1208310527, G3686629850, G3708519470, G371639923

OpenAlex ID: W4416433713

FWCI: 0.254

Cites: 30

Cited by: 1

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