Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Drug delivery systems (DDS) are promising tools to enhance antimicrobial Photodynamic Therapy (aPDT) by improving the targeted delivery and controlled release of photosensitizers. In this study, we introduce a light-responsive DDS based on curcumin-loaded mesoporous silica nanoparticles featuring a gold nanostar core and paraffin capping, designed specifically for near-infrared (NIR)-triggered photothermal release. This multicomponent nanoplatform uniquely combines photothermal activation with light-controlled drug delivery for antimicrobial applications. The synthesized nanoparticles exhibited a mean diameter below 500 nm, a polydispersity index of 0.154, and a surface charge of −21.9 mV. Upon NIR irradiation at 1200 J/cm 2, curcumin release was approximately 90%. In planktonic bacterial cultures, aPDT mediated by this system led to reductions of 3.16 log 1 0 and 2.18 log 1 0 in colony-forming units (CFUs) for Staphylococcus aureus and Pseudomonas aeruginosa, respectively. For bacterial biofilms, a higher curcumin concentration (1000 μg/mL) resulted in CFU reductions of 2.16 log 1 0 and 1.77 log 1 0 for S. aureus and P. aeruginosa, respectively. This study demonstrated a NIR-activated nanocarrier for the controlled release of curcumin and effective inactivation of both planktonic and biofilm-associated bacteria─offering a new approach to improve the precision and efficacy of aPDT.
Source: ACS Omega
Institutions: Universitat de València, Universidad Privada Franz Tamayo, Universitat Politècnica de València, Universidade Estadual Paulista (Unesp), Instituto de Salud Carlos III, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red, Instituto de Investigación Sanitaria La Fe, Centro de Investigacion Principe Felipe
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,935
Funders: Ministerio de Ciencia, Innovación y Universidades, Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Generalitat Valenciana, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, European Regional Development Fund, Agencia Estatal de Investigación, Centros de Pesquisa, Inovação e Difusão, Fundação Amazônia Paraense de Amparo à Pesquisa, Division of Graduate Education
Awards: G1009292636, G1422035950, G1622782223, G2262748287, G2458744160, G2772067330, G2811253794, G2823776494, G295657101, G3220251042, G3480869486, Mesoporous silica-coated gold nanostars for photodelivery of curcumin, G425668148, G451917667, G4526231891, G5657760404, G5838433224, G5967599077, G6191138830, G6247943665, G6903731458, G7084143925, G7434936867, G7903812426, CEPOF - Optics and Photonic Research Center, G87162555
OpenAlex ID: W4416434931