Work

Mesoblastic nephroma in a young Entlebucher Mountain Dog

Year: 2025

Type: article

Abstract: An intact 16-month-old female Entlebucher Mountain Dog in poor general condition was presented with clinical signs of gastrointestinal disease. Abdominal ultrasonography revealed a mass in the right kidney. Nephrectomy combined with ovariohysterectomy was performed. Histology revealed a mesenchymal tumour that was composed of neoplastic spindle cells forming interlacing fascicles, whorls and bundles, and embedded into a loose myxoid to dense collagenous stroma. Immunohistochemically, neoplastic cells diffusely labelled for vimentin and partially for S-100 protein and p75 NTR . Based on these results, the tumour was diagnosed as a classical variant of a congenital mesoblastic nephroma. The expression of p75 NTR has not been described in this tumour entity before and its significance with regard to tumour promoting or tumour suppressing function or indication of a neurogenic differentiation remains undetermined. After a 3-year follow-up the dog was clinically healthy, indicating a successful surgical treatment.

Source: Journal of Comparative Pathology

DOI: 10.1016/j.jcpa.2025.11.001