Hearing loss in French survivors of childhood and adolescent leukemia: impact on quality of life and schooling difficulties
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Hearing dysfunction following ototoxic or intensive cancer treatments is an underreported late effect among survivors of childhood and adolescent acute leukemia. The AUD&LEA project is the first study to examine, in a large cohort of childhood acute leukemia survivors: 1. the associated factors of hearing loss; 2. the association of hearing loss and the life of the individuals. METHODS: The AUD&LEA (AUDition & Leucémie Enfants et Adolescents) project was a cross-sectional study. The participants were included in the French LEA cohort which includes 18 French medical teams. The inclusion criteria of the patients were: childhood acute leukemia survivors, diagnosed before the age of 18 and after 1980, had a valid response (yes or no) regarding auditory sequela, and alive on December 31, 2022. The following data were collected: sociodemographics and clinical data, quality of life and schooling course. RESULTS: Among 6145 individuals, 1.45 % (95 % confidence interval [1.11-1.69 %]) persons were classified having a hearing loss. Compared to the individuals without hearing loss, those with hearing loss were significantly younger at the diagnosis and presented more often an acute myeloid disease. They also reported the worst level of quality of life and more often grade retention. CONCLUSION: Hearing loss should have consequences in the quality of life and the schooling course. It is essential to carry out systematic screening during and after the implicated treatments.
Authors: Sebastien Lazzarotto, Gérard Michel, Carine Domenech, Marie-Dominique Tabone, Sophie Ansoborolo, Jean-Hugues Dalle, Andre Baruchel, Aurélie Phulpin, Catherine Paillard, Virginie Gandemer, Laura Olivier, Corinne Armari-Alla, Maryline Poiree, Nicolas Sirvent, Justyna Kanold, Sandrine Thouvenin, Isabelle Pellier, Yves Reguerre, Pascale Schneider, Alaa Mustafa Shawket, David Romano, Zeinab Hamidou, Julie Berbis, Martin Postzich, Pascal Auquier, Karine Baumstarck
Institutions: Aix-Marseille Université, Centre d’Etudes et de Recherche sur les Services de Santé et la Qualité de Vie, Assistance Publique Hôpitaux de Marseille, Hospices Civils de Lyon, Sorbonne Université, Hôpital Armand-Trousseau, Assistance Publique – Hôpitaux de Paris, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Université Paris Cité, Hôpital Robert-Debré, Groupe Hospitalo-Universitaire Paris Nord, Hôpital Saint-Louis, Hôpitaux Universitaires de Strasbourg, Centre Hospitalier Universitaire de Rennes, Centre Hospitalier Universitaire de Toulouse, Centre Hospitalier Universitaire de Grenoble, Hôpital l'Archet, Centre Hospitalier Universitaire de Montpellier, Inserm, Centre Hospitalier Universitaire de Clermont-Ferrand, Centre Hospitalier Universitaire de Saint-Étienne, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Centre Hospitalier Universitaire de La Réunion, Centre Hospitalier Universitaire de Rouen
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,080
OpenAlex ID: W4416438778