Design, synthesis and structure–activity relationship analysis of dibenzodiazepinone derivatives against Osimertinib resistant NSCLC
Year: 2025
Type: article
Abstract: (2.7 μM) than osimertinib (6.5 μM). It effectively inhibited colony formation, migration of H1975™ cells, induced G0/G1 arrest, and promoted apoptosis through suppressing EGFR and AKT phosphorylation. These findings demonstrate the potential of optimizing the dibenzodiazepinone framework for developing novel potent molecules against osimertinib resistant NSCLC cells, providing valuable insights for future research.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00759c
Authors: Chengliu Jin, Zhen Zhang, Peng Liao, Chen Zhang, Hua Cao, Yan-Long Ma
Institution: Guangdong Pharmaceutical University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416438876