Work

Unveiling Neuropsychiatric Lupus: A Case of SLE Presenting With Depressive Symptoms and Literature Review

Year: 2025

Type: article

Abstract: A young woman presented with a rare depressive-onset manifestation and showed a poor response to antidepressant therapy. Subsequently, with the involvement of multiple organ systems, positive autoantibodies, and multiple lesions on head MRI, she was diagnosed with systemic lupus erythematosus (SLE). Following the initiation of immunosuppressive treatment, the patient experienced rapid improvement in both the physical symptoms of SLE and depressive manifestations. The underlying pathophysiological mechanisms linking depression in SLE patients are thought to involve inflammatory processes and microcirculatory dysfunction.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.71457

Authors: Yuqiong He, Qiuxiang Ou, Li Zhang

Institutions: Central South University, Second Xiangya Hospital of Central South University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820