Year: 2025
Type: article
Abstract: values ranging from 2 to 3 μM. Biochemical analysis confirmed that their mode of action is mediated by potent PPO inhibition, which further blocked heme production and damaged mitochondrial health status in the parasites. These findings enhance our understanding of oxadiazon's structural optimization and highlight its derivatives as promising early-stage candidates for developing effective therapies against toxoplasmosis in humans and other animals.
Source: RSC Medicinal Chemistry
DOI: 10.1039/d5md00888c
Authors: Samuel Kwain, Vikky Awasthi, Rajib Islam, Shivani Kore, Emma Polaski, Kerrick C. Rees, Zhicheng Dou, Daniel C. Whitehead
Institution: Clemson University
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4416439024