Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To classify serous effusions using the ISRSFC and assess malignancy risk across diagnostic categories, considering patient demographics and clinical features. Serous fluid cytopathology is a minimally invasive, cost-effective method for diagnosing benign and malignant conditions. The International System for Reporting Serous Fluid Cytopathology (ISRSFC) standardizes reporting, yet data from Saudi Arabia are limited. METHODS: A prospective observational study was conducted from October 2023 to June 2024. Serous fluid samples (peritoneal, pleural, pericardial) were stained with the Papanicolaou method and evaluated microscopically. RESULTS: Among 153 effusions, peritoneal (60.7%) was most common. Patients aged 41-66 comprised the largest group (41.2%). Cytologically, 36% were negative for malignancy, 19% atypia of undetermined significance (AUS), and 18.3% malignant. Risk of malignancy by ISRSFC category was: nondiagnostic (3.2%), negative for malignancy (5.4%), AUS (6.8%), suspicious for malignancy (52.7%), malignant (100%). Significant associations were found with clinical and demographic factors. CONCLUSION: The ISRSFC effectively classifies effusions and stratifies malignancy risk. Peritoneal effusion was most frequent, highlighting cytology's diagnostic value and the need for further regional studies.
Source: Saudi Medical Journal
Authors: Magdi M. Salih, Shatha Abdullah Alotaibi, Ashwag Mohammed Al Talhi, Manal Ali Hassan, Khwaimsa Mohammad Bhaket, Nesreen Ahmad Bakhsh
Institution: Taif University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Taif University
OpenAlex ID: W4416439143
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