Macrophages and TGFB signaling regulate fibrosis in the Escherichia coli -infected mouse prostate
Year: 2025
Type: article
Abstract: Prostatic/urethral fibrosis is an emerging cause of urinary voiding dysfunction in aging men and has been linked to prostate inflammation, but cellular mediators and mechanisms of this process are incompletely understood. We provide evidence that Ly6C hi monocytes and LYZ2+ myeloid cells are recruited to the E. coli infected mouse prostate. Macrophages in the infected prostate synthesize TGFB1 and stimulate collagen synthesis in LYZ2+ cells.
Authors: Brandon R. Scharpf, Jaskiran Sandhu, Hannah Ruetten, Hongtae Park, Robbie Manuel, Olivia Fox, Anne E. Turco, Shreya S. Nair, Elliot Heye, Marcela Ambrogi, Sneha Chandrashekar, Akhil Pidikiti, Allison Rundquist, Nicholas J. Steers, Lisa Arendt, Marulasiddappa Suresh, Douglas W. Strand, Chad M. Vezina
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G2378322779, G2664138453, G3517362731, Cellular and molecular mediators of fibrosis in the development of urinary tract dysfunction, G696271718, Prostate inflammation increases collagen and voiding dysfunction, G8442414799, University of Wisconsin Institute for Clinical and Translational Research, Bedside to bench resources for lower urinary tract research, UT Southwestern Medical Center Simmons Comprehensive Cancer Center, Laboratory Animal & Comparative Medicine Training, Molecular & Environmental Toxicology Predoctoral Training Program, Reproductive and Developmental Toxicity of Dioxin
OpenAlex ID: W4416439329