Topical calcipotriol versus liquid nitrogen spray in the treatment of palmoplantar warts: An observational study
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: ObjectivePalmoplantar warts are among the most common types of warts and are often challenging to treat. Currently, only a few effective treatments exist for palmoplantar warts. This study aimed to compare the efficacy and safety of 0.05% topical calcipotriol ointment and liquid nitrogen spray in the treatment of palmoplantar warts.MethodsFifty-eight adult patients with palmoplantar warts were randomly assigned to two groups. Thirty patients in Group A were treated with 0.05% topical calcipotriol twice daily, while twenty-eight patients in Group B received liquid nitrogen spray biweekly. Both treatments were administered for 8 weeks.ResultsStatistically significant reductions in wart number and size were observed in both groups at weeks 4 and 8; however, the differences between the two groups were not statistically significant. Most adverse events in the calcipotriol group were mild, while those in the liquid nitrogen group included pain (82.14%), vesicular lesions (78.57%), erythema (42.86%), bleeding (3.57%), and edema (3.57%).ConclusionsBoth treatments demonstrated comparable efficacy; however, topical calcipotriol was safer than liquid nitrogen spray for treating palmoplantar warts. The 0.05% topical calcipotriol ointment may represent a safer alternative to liquid nitrogen spray for the treatment of palmoplantar warts.
Authors: Nguyen Dac Khoi Nguyen, Tu Nguyen Anh Tran, Hao Trong Nguyen
Institution: Pham Ngoc Thach University of Medicine
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,155
OpenAlex ID: W4416440036