Work

Comparative evaluation of ADC and ADC ratio in differentiating Gleason Score 7 in prostate cancer imaging

Year: 2025

Type: article

Abstract: Background: (ratio of tumor-to-normal ADC) in differentiating these subgroups and to assess the influence of magnetic field strength (1.5 T vs. 3.0 T) on diagnostic performance. Methods: This retrospective study included 48 patients with histologically confirmed GS 7 PCa who underwent mpMRI at 1.5 T or 3.0 T. Two experienced radiologists independently and blindly delineated tumor and reference ROIs. Inter-observer agreement was evaluated using the intraclass correlation coefficient (ICC). Correlation, t-tests, and receiver operating characteristic (ROC) analyses were used to assess relationships, group differences, and optimal cut-off values. Results: achieved an AUC of 0.748 and mean ADC an AUC of 0.718 (p > 0.05). Conclusion: demonstrated high reproducibility and stable diagnostic performance across scanners, supporting its potential as a reliable imaging biomarker for prostate cancer grading.

Source: European Journal of Radiology Open

DOI: 10.1016/j.ejro.2025.100710