Work

Cyanidin-3-O-Glucoside Ameliorated Hepatic Steatosis in AGEs-rich MCD Diet Induced NAFLD Mice Model via Inhibiting Endoplasmic Reticulum Stress

Year: 2025

Type: article

Abstract: Non-alcoholic fatty liver disease (NAFLD) could be worsened by endogenous and exogenous advanced glycation end products (AGEs). This study investigated how exogenous AGEs exacerbate NAFLD and whether cyanidin-3-O-glucoside (C3G) as an anthocyanin could mitigate liver damage. Mice were fed with baked methionine-choline deficient (MCD) diet and treated with low or high-dose C3G gavage for six weeks. Baked MCD diet induced severe steatosis and inflammation, while C3G, particularly at high doses, reduced lipid droplet accumulation and hepatic inflammation. Proteomics revealed C3G modulated lipid metabolism, mitochondrial function, and endoplasmic reticulum pathways, and suppressed lipid synthesis enzymes such as CD36, ACC, FASN and FABP4. These findings highlight anthocyanins’ protective role in NAFLD by targeting lipid synthesis pathways, offering insights for dietary interventions and functional food development to combat metabolic liver disorders.

Source: Food Science and Human Wellness

DOI: 10.26599/fshw.2025.9250826

Authors: Xiaoyu Liu, Yangming He, Xia Li, Xu Wang, Weibin Bai, Xinwei Jiang

Institutions: Jinan University, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Natural Science Foundation of Guangzhou City, National Natural Science Foundation of China