Palladium-103 plaque radiation therapy for retinal angioma
Year: 2025
Type: article
Study design: Case Report
Abstract: Plaque radiation has been used in the treatment of angiomas of the choroid, retina, and vasoproliferative tumors of the retina. Herein, is presented the novel use of palladium-103 ( 103 Pd) plaque radiation as primary treatment for retinal angioma. Two patients presented with solitary peripheral retinal angiomas. Both initially progressed on observation and failed subsequent argon laser photocoagulation. Pre-treatment comparative dosimetry was performed to evaluate the available radiation sources palladium-103 ( 103 Pd), iodine-125 ( 125 I), and yttrium-90 ( 90 Y) for an equivalent tumor apex dose). Yttrium-90 plaque therapy offered the most favorable, measured intraocular dose distribution to the fovea, optic disc and lens for both patients. However, informed consent led to a patient preference for 103 Pd, due to its prior and more long-term follow-up after irradiation of choroidal hemangiomas, melanoma, and retinoblastoma. Each was treated to 103 Pd plaque apical doses of 50 and 60 Gray (Gy) over a 7-day period. Doses to fovea were very low at 1.3 and 1.7 Gy respectively. Both angiomas regressed over 1-year observation as evidenced by decreased tumor size, with resolution of retinal exudates, overlying retinal hemorrhage, and a localized retinal detachment. Vision was unchanged. 103 Pd plaque brachytherapy was utilized to treat two peripheral retinal vascular angiomas. Calculated doses to fovea and optic disc suggest no risk of radiation maculopathy or optic neuropathy. 103 Pd plaque brachytherapy was found to control tumor growth and reverse their exudation resulting in preservation of vision.
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,590
OpenAlex ID: W4416444150