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Glycosylation at the Crossroads of Cancer and Neurodevelopmental Disorders: A Shared Molecular Landscape

Year: 2025

Type: article

Abstract: Glycosylation as a central molecular mechanism linking cancer progression to NDDs. Center, the process of glycosylation which affects abnormal glycan expression, gene regulation, and immune system dysfunction. Left, basic features of tumorigenesis: immune escape, cell proliferation, and metastasis. Right, critical neurodevelopmental processes: synaptic plasticity, neuronal migration, and neuroimmune interactions. Key molecules contributing to both the pathobiology of cancer and NDDs are shown.

Source: European Journal of Neuroscience

DOI: 10.1111/ejn.70341

Authors: Panagiotis Sarantis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou

Institution: National and Kapodistrian University of Athens

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4416444775

FWCI:

Cites: 16

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