Work

Dual Catalytic Enantioconvergent Carbamoylation of Aziridines

Year: 2025

Type: article

Abstract: Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c15873

Authors: Liangliang Zhang, Huilin Liu, Tomás G. Santiago, Ruben Martin

Institutions: Institut Català d'Investigació Química, Barcelona Institute of Science and Technology, Universitat Rovira i Virgili, Institució Catalana de Recerca i Estudis Avançats

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500