Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase
Year: 2025
Type: article
Abstract: This study presents the first comprehensive phytochemical analysis of Hydrangea macrophylla var. acuminata leaves, resulting in the isolation of 41 secondary metabolites, including four new compounds: one phenolic (3) and three bis-iridoid glycosides (30–32). The inhibitory activities of these compounds against PTP1B and α-glucosidase were evaluated. Among them, compound 12 exhibited the most potent dual inhibition, with IC50 values of 8.0 ± 1.1 µM for PTP1B and 3.4 ± 0.2 µM for α-glucosidase. Compounds 8 and 9 showed notable α-glucosidase inhibitory activity, with IC50 values of 21.9 ± 0.4 µM and 43.8 ± 2.1 µM, respectively. Enzyme kinetics and molecular docking studies revealed their inhibition mechanisms and binding interactions. This study is the first detailed phytochemical investigation of H. macrophylla var. acuminata and highlights its potential as a natural source of PTP1B and α-glucosidase inhibitors. These findings underscore the plant’s promise for developing antidiabetic agents targeting PTP1B and α-glucosidase.
Authors: Thi Ly Pham, Viet Phong Nguyen, Thi Thuy An Nguyen, Byung Sun Min, Jeong Ah Kim
Institutions: Kyungpook National University, Daegu Catholic University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,306
OpenAlex ID: W4416447408