A new modic changes classification and its impact on posterior lumbar interbody fusion
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Current research on Modic Changes (MCs) in Posterior Lumbar Interbody Fusion (PLIF) has predominantly focused on types 1, 2, and 3; however, findings remain inconsistent. To address this gap, we introduce a novel classification system based on endplate sclerosis status (sclerotic vs. non-sclerotic) to better evaluate the influence of MCs on PLIF outcomes. METHODS: Patients were divided into Group A (normal endplates), Group B (MCs without endplate sclerosis), and Group C (MCs with endplate sclerosis), with fifty patients in each group. VAS and ODI scores were recorded preoperatively, postoperatively, and during follow-up to assess clinical outcomes. At least one year after surgery, CT scans were performed to evaluate postoperative cage subsidence and bony fusion. RESULTS: The postoperative cage subsidence rate recorded were 4% for Group A, 16% for Group B, and 2% for Group C, with a statistically significant difference (P < 0.05). The postoperative bony fusion rate were 98% for Group A, 96% for Group B, and 80% for Group C, with a statistically significant difference (P < 0.05). At the final follow-up, the Visual Analog Scale(VAS) and Oswestry Disability Index(ODI) scores in Group C were significantly higher than those in Groups A and B (P < 0.05), indicating worse clinical outcomes. CONCLUSION: MCs without endplate sclerosis increase the risk of cage subsidence after PLIF surgery but do not effect clinical outcomes. MCs with endplate sclerosis are associated with a reduced bony fusion rate following PLIF surgery, leading to worse long-term clinical outcomes.
Source: BMC Musculoskeletal Disorders
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W4416452214