Work

Mechanism and research progress of MAPK signaling pathway in myocardial fibrosis

Year: 2025

Type: article

Abstract: Myocardial fibrosis (MF) is a hallmark pathological outcome of many cardiovascular diseases and a key component of cardiac remodeling. The p38 MAPK, JNK, and ERK signaling pathways are central to this process. This review summarizes the roles and interactions of these factors in MF and identifies relevant drug and non-pharmacological therapies targeting these pathways.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1667568

Authors: Jinqiao Wu, Min Chen, Ze Peng, Yao Sun, Juan Jin

Institutions: Heilongjiang University of Chinese Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801