Dosimetric impact of bladder volume variation on online adaptive radiotherapy for cervical cancer based on cone-beam computed tomography and clinical management strategies
Year: 2025
Type: article
Abstract: Background: During cervical cancer radiotherapy, unstable bladder volume can compromise target accuracy and increase radiation exposure to organs at risk (OARs). Although online adaptive radiotherapy (ART) can correct for interfractional variations, intrafractional bladder filling may still lead to dose deviations. This study aimed to evaluate the dosimetric optimization of ART for interfractional bladder fluctuations, analyze the impact of intrafractional dynamics, and evaluate the clinical benefits of personalized bladder management. Methods: . Dosimetric comparisons were performed between ART and IGRT plans, and intrafractional bladder volume changes and their dosimetric impact were analyzed. Results: ; P<0.01), and (III) organ stability (no significant rectal or femoral head dose changes). Conclusions: ART for cervical cancer mitigates interfractional bladder-related dosimetric variations, while personalized bladder management enhances intrafractional stability. Combining ART with personalized bladder protocols for cervical cancer ensures target coverage while simultaneously enhancing protection of OARs.
Authors: Yingnan Qi, Xuemei Chen, Feng Chi, Zhanlin Chen, Yu Luo, Senkui Xu, Yilin Wang, Lintao Shang, Tong Wang, Xiuying Mai, Yaoyao Lin, Weizheng Zheng, Yunfei Feng, Foping Chen, Xiaobo Jiang
Institution: Sun Yat-sen University Cancer Center
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4416455069
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