The cellular economy while crafting regulatory processes relies on protein intrinsic disorder: how and why precision comes at a cost in protein structure
Year: 2025
Type: article
Abstract: Regulatory proteins, including those involved in signal transduction, invariably have intrinsic disorder. Enzymes, on the other hand, rely on unique structures for their pre-formed active sites to carry out catalysis. Disorder-promoting amino acids are shown to be non-essential amino acids, for which there are minimum biosynthetic costs. Therefore, disorder costs less to cells.
Source: Cell Communication and Signaling
Authors: Munishwar Nath Gupta, Vladimir N. Uversky
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
OpenAlex ID: W4416455918