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Knowledge and Support for Antimicrobial Stewardship Does Not Necessarily Translate into Good Practice: Survey in a Tertiary Hospital in Moldova, May–June 2024

Year: 2025

Type: article

Abstract: Background/Objectives: Antimicrobial resistance (AMR) is an increasing problem globally, largely driven by the overuse and misuse of antibiotics. In Moldova, physicians are frequently not following recommendations regarding the use of antimicrobials. Despite the adoption of a national strategy to combat AMR, information on healthcare professionals’ knowledge, attitudes, and practices (KAP) related to antimicrobial stewardship (AMS) remains limited. This study aimed to assess KAP related to AMS among staff at a tertiary hospital. Methods: We surveyed employees of the Republican Clinical Hospital between 20 May and 30 June 2024. We interviewed doctors, nurses, pharmacists, clinical pharmacologists, and epidemiologists using a structured, self-administered questionnaire. The instrument assessed their KAP regarding antimicrobial stewardship. We analyzed the data collected using descriptive statistics and tests of association. Results: Among 138 participants, 65% were female and 54% were nurses. A high proportion demonstrated good knowledge (87%) and a positive attitude (78%) towards AMS. However, only 31% reported good stewardship-related practices. Significant associations were observed between knowledge and attitude (p < 0.001), and between knowledge and practice (p = 0.013). No significant association was found between attitude and practice (p = 0.160). Conclusions: These findings reveal a disconnect between knowledge, attitudes, and practical implementation of AMS principles. While healthcare professionals were knowledgeable and well-intentioned, practice remains inconsistent. This suggests that effective AMS interventions must combine individual training with structural support at the institutional level. Tailored strategies should address both general awareness and hospital-specific factors contributing to AMR.

Source: Antibiotics

DOI: 10.3390/antibiotics14121180

Authors: Nadejda Morărescu, Pawel Stefanoff

Institution: European Centre for Disease Prevention and Control

Language: English

Topic: Antibiotic Use and Resistance

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499