CUP global framework for the review of the biologic pathways linking diet, nutrition, body weight, and physical activity with cancer incidence – Updated to version 2
Year: 2025
Type: other
Abstract: This current framework (version 2) updates the previous one published within the WCRF Gateway on Health Open Research (publication data of version 1: 12th February 2025). The purpose of the Framework is to provide guidance on how to: identify, review, and summarise the biological mechanisms that underpin the associations between diet, nutrition, body weight, and physical activity and cancer incidence found within CUP Global assess the strength of evidence that a given biological mechanism operates between an exposure and outcome of interest These biological plausibility investigations apply to 1) exposures with an established link to cancer (strong evidence in CUP/CUP Global) and for which there are strong mechanistic data, but further work is needed (for example, a poorer understanding of the evidence for certain cancer sites); 2) exposures with a strong epidemiological link to cancer (strong evidence in CUP/CUP Global) but with limited mechanistic understanding; 3) exposures with a putative epidemiological link to cancer (limited–suggestive evidence in the CUP/CUP Global) for which more robust mechanistic data would strengthen conclusions. Note that mechanisms evaluated using this Framework are defined as biological processes linking diet, nutrition, body weight, and physical activity and cancer incidence. The focus is primarily on molecular mechanisms but may expand to physiological mechanisms depending on the research question. Other mechanisms, for example those involving the social determinants of health, are likely to be at play in cancer risk, but have historically fallen outside of WCRF International’s research. WCRF International is seeking to clarify how these other mechanisms might be investigated within CUP Global in the future.
Authors: Laure Dossus, Marc J. Gunter, Esther M. González-Gil, Beatrice Lauby-Secretan, Nahid Ahmadi, Panagiota Mitrou, Helen Croker, Christelle Clary, Vanessa L.Z. Gordon-Dseagu, Nigel Brockton, Dieuwertje E. Kok, Fred K. Tabung, Suzanne D. Turner, Lee W. Jones, Zdenko Herceg, Richard Simpson, Stephen Hursting, Sarah J. Lewis
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416461395
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