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Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice

Year: 2025

Type: article

Abstract: A Crimean-Congo hemorrhagic fever virus replicon particle vaccine was evaluated for long-term immunity and efficacy in mice. IgG responses persisted up to 18 months, with similar titers across dosing strategies through 12 months. Protective efficacy reached ≥75% at 6 months (prime-only) and up to 12 months (prime-boost). Booster dosing enhanced antibody avidity, effector function, and improved long-term protection. These findings support durable immunity from single or boosted vaccination.

Source: npj Vaccines

DOI: 10.1038/s41541-025-01293-9

Authors: Teresa E. Sorvillo, Elif Karaaslan, Katherine A. Davies, Stephen R. Welch, Florine E. M. Scholte, JoAnn D. Coleman-McCray, Virginia Aida-Ficken, Scott D. Pegan, Éric Bergeron, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler

Institutions: Centers for Disease Control and Prevention, CDC Foundation, Agricultural Research Service, United States Department of Agriculture, Auburn University, University of California, Riverside

Language: English

Topic: Viral Infections and Vectors

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: U.S. Department of Energy, U.S. Department of Agriculture, Oak Ridge Associated Universities, National Institutes of Health, Centers for Disease Control and Prevention, Oak Ridge Institute for Science and Education, Agricultural Research Service, National Institute of Allergy and Infectious Diseases

Awards: G1091427512, G3066948647, G4336470938, Origin of the innate immunity suppression caused by nairovirus' protease activity, Identification of GP38 and NP antibodies and their protective mechanisms against CCHFV

OpenAlex ID: W4416470664

FWCI: 0.706

Cites: 40

Cited by: 1

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