Work

Deoxygenative Reactions of Aldehydes Catalyzed by Iron Porphyrins

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Stereocontrolled radical reactions have emerged as powerful strategies for advancing stereoselective organic synthesis, yet radical transformations employing iron-based catalysts remain rare. Here, we report that iron porphyrins catalyze the deoxygenative transformations of aldehydes, affording alkenes via homocoupling or cyclopropanes through cross-coupling with styrene derivatives. These transformations are proposed to begin with the formation of a β -Fe(III)-alkoxy carbon radical from Fe(II) porphyrin and the aldehyde substrate, followed by a radical coupling and deoxygenation cascade.

Source: ACS Catalysis

DOI: 10.1021/acscatal.5c06407

Authors: Erkan Ertürk, Mehmet Ulutürk

Institutions: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK Marmara Research Center

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu