Stage-Specific Predictors and Outcomes of Colistin-Associated Acute Kidney Injury in Surgical and Medical ICU Patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Acute kidney injury (AKI) is a critical concern in intensive care unit (ICU) patients, especially those treated with colistin. However, existing research often includes mixed patient populations, including non-ICU patients, and lacks stratification of factors associated with varying severities of AKI. The AKI prevalence and predicting variables should be further explored due to the diversity in AKI development and outcomes in colistin-treated ICU patients. Methods: This study analyzed electronic medical records of 174 surgical and medical ICU patients treated with intravenous colistin at a tertiary university hospital. Multinomial regression analysis was used to analyze the prevalence of AKI stages using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria and identify predictive factors across different stages of AKI. Results: < 0.05). Colistin dosage was as a significant predictor when distinguishing Stage 1 AKI from no AKI (adjusted OR 1.46, 95% CI: 1.09-1.94), but was not identified as a significant predictor for the progression to Stages 2 to 3 AKI. Conclusion: The impact of colistin-associated nephrotoxicity in ICU patients is primarily at the initial stage of AKI and does not extend to more advanced stages. Patient safety may be enhanced by using the APACHE II score as one of the deciding variables when deciding between colistin and other antibiotic treatments, particularly for vulnerable critically ill patients.
Source: Hospital Pharmacy
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4416479664