Work

Social Genomic Mechanisms of Health Disparities Among Adolescent/Young Adult Survivors of Hodgkin and Non-Hodgkin Lymphoma: ECOG-ACRIN E

Year: 2025

Type: article

Abstract: Research in human social genomics maps molecular pathways through which social and psychological factors regulate gene expression in immune cells and tumor tissue, thus affecting chronic disease progression, symptom development, antiviral resistance, morbidity, and mortality.In many cases, psychosocial factors trigger neural and endocrine responses that regulate expression of genes involved in cancer progression (inflammation, metastasis, and treatment resistance) and immune function (stimulating inflammatory genes and suppressing antiviral gene transcription, as observed in the "Conserved Transcriptional Response to Adversity"/CTRA transcriptome signature).However, nothing is known about how such effects impact Adolescent and Young Adult (AYA) cancer survivors.This study

Source: Journal of Adolescent and Young Adult Oncology

DOI: 10.1177/21565333251399057