Work

Beyond the Pelvis: Brain Metastases in Cervical Cancer – A Case Series from a Low-Middle-Income Country

Year: 2025

Type: article

Abstract: Brain metastases from cervical cancer are exceedingly rare and pose significant clinical challenges, particularly in low- and middle-income countries (LMICs), where access to advanced diagnostics and therapies may be limited. We report two cases of cervical carcinoma with brain metastases managed at a tertiary center in Indonesia, each illustrating distinct histopathologic subtypes and metastatic trajectories. The first case involved a 31-year-old woman with a grade II neuroendocrine carcinoma who developed intracranial recurrence 11 months after achieving a complete response to concurrent chemoradiotherapy. In the second case, a 46-year-old woman with poorly differentiated non-keratinizing squamous cell carcinoma developed progressive brain and pulmonary metastases during adjuvant radiotherapy. Both patients underwent craniotomy for gross total resection of symptomatic brain lesions, followed by adjuvant radiotherapy. The surgical intervention led to substantial neurological improvement in both cases, underscoring the role of symptom-directed neurosurgical palliation even in the setting of disseminated disease. These cases highlight the need for heightened clinical vigilance, individualized multidisciplinary management, and strategic application of available resources to improve outcomes in patients with central nervous system involvement from cervical cancer, especially within resource-constrained healthcare systems.

Source: International Journal of Women s Health

DOI: 10.2147/ijwh.s547145

Authors: Candra Sibarani, Dodi Suardi, Siti Salima, Nathania Nathania, Nicholas Adrianto

Institutions: Dr. Hasan Sadikin General Hospital, Padjadjaran University, Atma Jaya Catholic University of Indonesia

Language: English

Topic: Brain Metastases and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836