Year: 2025
Type: article
Abstract: The advent of precision medicine has spotlighted subunit and peptide-based vaccines, which offer high safety but often require potent adjuvants to enhance immunogenicity. Self-assembled peptides have emerged as a promising adjuvant platform due to their ease of synthesis, excellent biocompatibility, and tunable structural properties. Recent advances highlight their potential in boosting vaccine efficacy, with self-assembled peptides forming highly ordered architectures that are conducive to immune system activation. This review discusses the key factors driving peptide self-assembly and explores their evolving role as innovative vaccine adjuvants, alongside challenges and future development directions.
Source: Vaccines
Authors: Miao-Miao Zhang, Ji Zhu, Zhao-Yi Wang, Yu-Lun Bai, Hai-Bo Li, Buhe Nashun, Yue Jiang
Institutions: Army Medical University, Inner Mongolia University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
Award: G5675496270
OpenAlex ID: W4416505238