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Adipose tissue releases nucleosides

Year: 2025

Type: article

Abstract: Adipose tissue inflammation contributes to the morbidity and mortality of obesity. Adipocytes are known to release uridine and adenosine, but information on other nucleosides is lacking. As nucleosides can induce inflammation, we characterized nucleoside release from mouse and human adipose tissue. Adipose tissue released adenosine/deoxyadenosine, guanosine/deoxyguanosine, and uridine ex vivo. Nucleoside secretion was associated with adipose tissue expression of inflammatory cytokines. This represents a new mechanism by which obese adipose tissue may develop inflammation.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00695.2025

Authors: Jing Zhang, Thuc Le, Veronica Ruiz-Torres, Michael Cohen, Vladislava Paharkova, Evan Abt, Hiba S. Alnajjar, Jia Tan, Khalid Rashid, Anthony E. Jones, Andréa B. Ball, Ajit S. Divakaruni, Rebecca L. Paszkiewicz, Praveen Bandaru, Julia J. Mack, Julianne W. Ashby, Jiyoon Kim, Gang Li, Caius G. Radu, Steven D. Mittelman

Institutions: University of California, Los Angeles, Universitat de Miguel Hernández d'Elx, California NanoSystems Institute, Terasaki Foundation

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of General Medical Sciences, Jonsson Comprehensive Cancer Center

Awards: Adipocytes are Important Players in the Acute Lymphoblastic Leukemia Microenvironment, Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancer, Understanding How Metabolic Cofactors Control Cell Function and Fate

OpenAlex ID: W4416505993

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