Work

Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity

Year: 2025

Type: article

Abstract: Maternal obesity increases risk for preterm birth and neonatal oxygen exposure. We tested whether hyperoxia (80% O 2 , P3–P10) worsens maternal obesity-induced hypertension. At 14 wk, BP measured by telemetry showed that hyperoxia unexpectedly lowered BP in lean and obese offspring and attenuated cardiac dysfunction in obese offspring. These findings indicate that neonatal hyperoxia does not exacerbate maternal obesity-induced hypertension and may mitigate early cardiac dysfunction.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00221.2025

Authors: Jussara M. do Carmo, John E. Hall, Xuemei Dai, Emily Ladnier, Zhen Wang, Alan J. Mouton, Alexandre A. da Silva

Institution: University of Mississippi Medical Center

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases

Awards: G1422855837, G182294559, G3016395338, G5443733967, G754882420, Cardiorenal and Metabolic Diseases Research Center, Long-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspring, Mississippi Center for Clinical and Translational Research, Cardiac protective mechanisms of melanocortin system activation

OpenAlex ID: W4416507289

FWCI:

Cites: 25

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