Work

FMRP restoration in parvalbumin interneurons: A circuit-specific improvement of visual learning in fragile X syndrome

Year: 2025

Type: article

Abstract: cON/PV-Cre). Silicon probe recordings of V1 showed that targeted restoration rescued frequency and duration of oscillatory responses and improved direction tuning deficits seen in FX. These mice also exhibited improved performance in a visual learning task and decreased hyperactivity. Our findings support an important role of PV+ interneurons in visual learning and memory, suggesting promising avenues for circuit-specific therapeutic interventions in FX syndrome.

Source: iScience

DOI: 10.1016/j.isci.2025.114132

Authors: Sanghamitra Nareddula, Violeta Saldarriaga, Xinwan Hu, Paige Alyssa Edens, Mia Fehlinger, Alexander A. Chubykin

Institution: Purdue University West Lafayette

Language: English

Topic: Genetics and Neurodevelopmental Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240