Work

Sika deer bone peptide attenuates ovariectomy-induced osteoporosis in mice via PPAR-γ/Axin2/Wnt signaling pathway

Year: 2025

Type: article

Abstract: Sika deer bone peptides (DBP-1-3) were extracted and purified from fresh deer bones. In ovariectomized (OVX) osteoporotic mice, DBP-1-3 increased serum calcitonin (CT), estradiol (E2), and 1,25(OH) 2 D 3 while reducing Ca 2+ and bone gla protein (BGP). Micro-CT analysis revealed improved trabecular bone structure, with increased bone volume/total volume (BV/TV), trabecular number (Tb.N), and thickness (Tb.Th), and decreased trabecular separation (Tb.Sp). Mechanistically, DBP-1-3 downregulated PPAR-γ and Axin2 while upregulating β-catenin, suggesting inhibition of the PPAR-γ/Axin2 pathway and activation of Wnt signaling. These findings indicate that DBP-1-3 alleviates osteoporosis by modulating bone metabolism and enhancing bone microstructure, potentially via PPAR-γ/Axin2/Wnt regulation. • DBP-1-3 elevates serum calcitonin (CT) while reducing bone Gla protein (BGP). • DBP-1-3 raises E2 and 1,25(OH)₂D₃, but lowers serum Ca 2+ . • DBP-1-3 stimulates osteoblast activity, bone mineralization, and formation. • DBP-1-3 increases the thickness and number of bone trabeculae. • Its mechanism may involve inhibiting PPAR-γ/Axin2 and activating Wnt signaling.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2025.107108

Authors: Guangchen Liu, Yue Ma, Guangxin Yuan, Hang Zhao, Ruofeng Yin

Institutions: Jilin University, Changchun DongFang Vocational College, Beihua University

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800