High HBV seroprotection rates in infants born to people with HIV and HBV infection in sub-Saharan Africa
Year: 2025
Type: article
Abstract: There is little data on hepatitis B surface antibody (anti-HBs) responses in HIV-exposed, uninfected (HEU) infants born to people living with HIV and hepatitis B virus infection (HBV) (HEU-HBV). We examined anti-HBs titers in infants in a post-hoc analysis of the HIV Prevention Trials Network (HPTN) 046 trial. Thirty-three infants were tested for anti-HBs at 6 and 12 months. Of these, 84.8 % had a protective response (anti-HBs >10 IU/ml) at 6 months, and 97 % had anti-HBs >10 IU/ml at 12 months. Infants with low birth weight ([LBW] ≤2500 g) had lower median anti-HBs titers at 6 and 12 months (472 IU/mL and 48 IU/mL, respectively) compared to infants without LBW, although this was not statistically significant. Anti-HBs titers at 6 and 12 months in HEU-HBV are similar to those in HIV unexposed, uninfected (HUU) infants.
Source: Vaccine X
Authors: Neaka Mohtashemi, Julia Spaczai, Rong Guo, Chi-hong Tseng, Mary C. Cambou, Lynda Emel, Hannah Ship, Tian-hao Zhang, Shih-Hsin Chiu, Lynda Stranix-Chibanda, Tsungai Chipato, Kenneth Kintu, Karim P. Manji, Dhayendre Moodley, Judith S. Currier, Chloe L. Thio, Yvonne Maldonado, Debika Bhattacharya
Institutions: University of California, Los Angeles, Fred Hutch Cancer Center, University of Zimbabwe, MUJHU Research Collaboration, Muhimbili University of Health and Allied Sciences, Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Johns Hopkins University, Stanford University
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,440
Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, International Maternal Pediatric Adolescent AIDS Clinical Trials Network, National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W4416528794