Work

Impact of cerebral vasospasm therapy on nimodipine exposure in subarachnoid hemorrhage: A population pharmacokinetic study

Year: 2025

Type: article

Abstract: BACKGROUND: ) - an unexplored pharmacokinetic aspect. METHODS: . RESULTS: in the final pharmacokinetic model, with BSA exerting a stronger and more consistent effect than MAP. Beyond MAP's own limited effect, hemodynamic augmentation therapy per se had no significant influence on nimodipine clearance. CONCLUSIONS: in contrast to patient's BSA, and, to a clinically irrelevant extent, MAP level.

Source: Journal of the Neurological Sciences

DOI: 10.1016/j.jns.2025.125666