Work

Antiproliferative and Apoptotic Effects of Lavandula officinalis In Vitro by Inhibiting HeLa Cancer Cell Growth and Migration

Year: 2025

Type: article

Abstract: The most prevalent cancer in women is cervical cancer, which is impacted by lifestyle choices, inadequate healthcare, and HPV exposure. The medicinal qualities of lavender, or Lavandula officinalis, include antibacterial, anti-inflammatory, and antioxidant actions. The antiproliferative and apoptotic effects of lavender on HeLa cervical cancer cells were evaluated in this study with doses ranging from 100 to 500 µg/mL. The results indicated that cell viability had significantly decreased (94.1 ± 7, 53.4 ± 4, 36.3 ± 2, respectively, p < 0.05). At 400 and 500 µg/mL, lavender inhibited bigger lesions and boosted apoptosis. MMP-2 expression dropped by 9%, 19%, 38%, and 58% at the same concentrations, whereas caspase-3 expression rose by 8%, 50%, 90%, and 110% at 200-500 µg/mL. According to these results, lavender may prevent cervical cancer from growing, migrating, and spreading.

Source: Biotechnology and Applied Biochemistry

DOI: 10.1002/bab.70095

Authors: Abdulwahab Ali Abuderman, Musthaq Ahmed Mohamed, Faziljon Rasulov, Rakhimova Khusnidakhon Abdukarimova, Abdujabborova Charosxon Sanjerbek, Kayumov Ganisher Olimovich

Institution: Prince Sattam Bin Abdulaziz University

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Prince Sattam bin Abdulaziz University, Deanship of Scientific Research, Prince Sattam bin Abdulaziz University