Work

Optimization of Lipid-Coated Mesoporous Silica Nanoparticles for BBB Targeted Delivery of 2-PAM to the CNS

Year: 2024

Type: report

Abstract: Background Methods Future Directions▪ Use ssDNA to evaluate biodistribution of BBB-targeted LC-MSNs ▪ Continue optimizing lipid formulations to improve delivery to the brain or seek alternative nanoparticle platforms that show improved 2-PAM loading and BBB-targeting, such LNPs Key Results and Discussion

DOI: 10.2172/3004363

Authors: Sandia National Laboratories (SNL-CA), Livermore, CA (United States), Genesis Lopez-Cazares, Defense Threat Reduction Agency, USDOE National Nuclear Security Administration (NNSA), Hemant Choudhary, Jennifer Schwedler, Christopher Sumner, Steven Branda, Oscar Negrete, Dina Weilhammer, Thomas Mulhern, Rebeccah Luu, Jeffrey Borenstein

Institutions: Sandia National Laboratories California, Lawrence Livermore National Laboratory

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: U.S. Department of Energy, National Nuclear Security Administration, Sandia National Laboratories

Awards: G11630931, G2214935549, G413247060, G4903105778, G5339743583, G855168022

OpenAlex ID: W4416535845

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