Work

Serine/threonine kinase 32 family proteins: The potential multifaceted regulators in cancer

Year: 2025

Type: article

Abstract: • The dysregulation of STK32 kinases is observed in cancer. • STK32 kinases exhibit tissue-specific oncogenic roles across malignancies. • Structural features and unique activation mechanisms of STK32 are detailly described. • STK32s are emerging as biomarkers and therapeutic targets for cancer treatment. As a subgroup of AGC kinases, serine/threonine kinase 32 family (STK32, also known as Yet Another Novel Kinases family) consists of three members: STK32A, STK32B and STK32C. Recently, emerging evidences have implicated the aberrant expression and dysregulated functions of STK32 kinases in human malignancies. However, there is a lack of systematic review on this topic. Here, we aim to detailly examine the expression and functional features of STK32 family kinases within the context of present reports and public datasets related, and outline current understanding on the multifunctional roles and up-stream regulatory mechanisms and down-stream effectors of STK32 kinases to highlight key research focus for future exploration and provide rationale for developing STK32-targeted therapeutics in cancer.

Source: Translational Oncology

DOI: 10.1016/j.tranon.2025.102608

Authors: Longqiao Liu, Yuan Feng, Yang Liu, Lin Cheng, Peng Cheng

Institutions: First Hospital of China Medical University, China Medical University, Sheng Jing Hospital

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390