Airway immunometabolic responses during pulmonary bacterial and viral infections
Year: 2025
Type: article
Abstract: Airway infections caused by viral and bacterial pathogens pose a significant threat to human health, with the COVID-19 pandemic serving as a stark reminder of their detrimental impact. This review explores the critical role of metabolism in determining the outcome of respiratory infections. It covers fundamental concepts in immunometabolism and details how common pathogens exploit the host metabolism to dysregulate immune responses or evade immune clearance. We further consider how immune-signaling metabolites can directly drive pathogen evolution, emphasizing the importance of a better understanding of host-pathogen metabolic interactions in developing effective new therapies.
Source: Cell Reports
Authors: Ridhima Wadhwa, Eric Tang, Lok Yin Roy Wong, Tania Wong Fok Lung
Institution: Rutgers New Jersey Medical School
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4416542945