Ubiquitin-proteasome pathway activation in the diaphragm of humans with reflux esophagitis
Year: 2025
Type: article
Study design: Observational Study
Abstract: This study demonstrated, for the first time, an increased activation of the ubiquitin-proteasome pathway and elevated MuRF-1 expression in the crural diaphragm of humans with moderate reflux esophagitis. It showed a positive correlation between the supine reflux time and MuRF-1 expression, suggesting a molecular mechanism associated with diaphragm fiber atrophy and weakness. These findings highlight a potential link between diaphragm degradation and reflux esophagitis, which may modulate gastroesophageal reflux and symptoms.
Institution: Universidade Federal do Ceará
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: G3309768582, G5823892746
OpenAlex ID: W4416545179