Work

Anti‐Aging Activity of Rosa roxburghii Nano‐Emulsion in Caenorhabditis elegans : Preparation, Characterization, and Evaluation

Year: 2025

Type: article

Abstract: The triterpenoids in Rosa roxburghii fruit (RRF) show various pharmacological activities such as antioxidant, anti-ageing, and anti-atherosclerotic. However, the therapeutic potential of these triterpenoids is limited by poor aqueous solubility, low bioavailability, and rapid systemic clearance, which can hinder their oral effectiveness. The objective of this study was to prepare an RRF nano-emulsion (RRFNE), which is conducive to enhancing the bioactivity of RRF following oral administration. The polydispersity index of RRFNE was 0.18, diameter 43.95 nm, zeta potential 36.37 mV, and triterpenoids loading 25.02 mg/g. Compared to RRF-100, the longest lifespan of RRFNE-100 was extended by 8.58%. The activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase in RRFNE-100 increased by 11.33%, 16.19%, and 5.37% (p < 0.01), respectively, and malondialdehyde levels decreased by 8.98%. Additionally, RRFNE enhances the antioxidant capacity of C. elegans by activating the expression of SIR-2.1, DAF-16, and SOD-3, thus extending the nematodes' lifespan without affecting their reproductive ability.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202502105

Authors: Xiaowei Zhou, Xiaojuan Li, Gaigai Xu, Bing Bai, Zixiu Wang

Institutions: Zhengzhou University of Light Industry, Gannan Medical University

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Henan Provincial Science and Technology Research Project