Work

Intratumoral microbiota-derived S1P sensitizes the combination therapy of capecitabine and PD-1 inhibitors

Year: 2025

Type: article

Abstract: T cell expansion and exhausted T cell subset reduction within TME. To conclude, these findings highlight microbial sphingolipids as potential predictive biomarkers for strategies of targeting intratumoral microbiota in CRC management.

Source: iScience

DOI: 10.1016/j.isci.2025.114202

Authors: Chen-Shu Dai, Tian-Tian Qi, Hui-Ling Shang, Ri-Hua Xie, Hao Liu, Zhen-Ming Liu, Yi-Min Cui, Yu-Hang Zhang

Institutions: Wenzhou Medical University, Peking University First Hospital, Xuzhou Rehabilitation Hospital, Foshan Maternity and Child Health Care Hospital, Southern Medical University, Peking University, State Key Laboratory of Natural and Biomimetic Drugs

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: China Association for Science and Technology, Peking University First Hospital, National Natural Science Foundation of China, Natural Science Foundation of Beijing Municipality, Beijing Association for Science and Technology

Awards: G1031354568, G2133261492, G2140794832, G2328215515, G2690896078, G4303923488, G4397610360, G4537749473, G5121502576, G6405304578

OpenAlex ID: W4416548957

FWCI: 1.49

Cites: 27

Cited by: 4

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