Work

Multidisciplinary Management of a Rare Primary Cardiac Angiosarcoma

Year: 2025

Type: article

Abstract: BACKGROUND: Primary cardiac tumors are exceptionally rare, with an autopsy incidence of only 0.001% to 0.03%. Angiosarcoma represents the most common subtype of cardiac sarcomas, which account for approximately 95% of malignant cases. CASE SUMMARY: A 30-year-old woman presented with chest tightness and dyspnea. Imaging revealed a 65 × 47 mm right atrial mass. She underwent complete surgical resection, with pathology confirming intimal sarcoma. Adjuvant paclitaxel/cisplatin chemotherapy was administered. Short-term follow-up showed no recurrence or metastasis. DISCUSSION: Cardiac angiosarcoma remains a therapeutic challenge with poor prognosis, necessitating multimodal management centered on complete surgical resection and adjuvant chemotherapy. Diagnosis relies heavily on advanced imaging, while definitive confirmation requires histopathological examination. Future research should prioritize targeted therapies and immunotherapies, supported by international collaboration to improve outcomes for this rare malignancy. TAKE-HOME MESSAGE: This case demonstrates that early diagnosis, complete resection, and adjuvant chemotherapy are crucial for managing this highly lethal disease with poor prognosis.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2025.106422

Authors: Tao Zhang, Xiaojie Zhang, Xiaoyan Sun, Cai Cheng

Institution: Second Affiliated Hospital of Zhejiang University

Language: English

Topic: Cardiac tumors and thrombi

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850