Reducing variability in tissue sodium and potassium measurement: validation of microwave digestion for cardiovascular research
Year: 2025
Type: article
Abstract: Tissue sodium is increasingly linked to cardiovascular pathophysiology, yet current measurement methods are slow, costly, and inconsistent. In this study, we quantified the variability of sodium and potassium assessment across human and rodent tissues. We show that ashing contributes to measurement bias, whereas microwave digestion offers a faster, more reproducible, and accessible workflow compared with dry ashing. This approach enables standardized electrolyte analysis to advance cardiovascular research.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Awards: G8692185392, G899658177
OpenAlex ID: W4416552569