The Reporting and Methodological Recommendations for Observational Studies Estimating the Effects of Deprescribing Medications (REMROSE‐D) ISPE‐Endorsed Guidance
Year: 2025
Type: article
Abstract: PURPOSE: Pharmacoepidemiologic studies on deprescribing are challenging to implement, yet little guidance exists on methods to avoid bias and minimum reporting for replicability and appraisal. We developed consensus recommendations for the methods and reporting of observational studies that aim to examine the effects of deprescribing. METHODS: We formed candidate recommendations based on our prior systematic review that methodologically appraised observational studies on deprescribing. We then conducted a two-round modified Delphi process with researchers working in deprescribing pharmacoepidemiology to refine, select, and reach consensus on recommendations for a checklist based on > 70% agreement of their importance. We termed this list the REMROSE-D (Reporting and Methodological Recommendations for Observational Studies estimating the Effects of Deprescribing medications) guidance. RESULTS: Twenty-three candidate recommendations were presented to the Delphi panel. The round 1 survey was completed by 55 participants, and 18 of the 23 candidate recommendations were selected for inclusion. Five candidate recommendations without consensus plus two additional items suggested by participants were included in a round 2 survey of 25 deprescribing researchers. Five of these seven items garnered consensus for inclusion, and two were excluded. The final REMROSE-D guidance contains 23 recommendations for the methods and reporting of observational research on deprescribing. CONCLUSION: To ensure rigor and reproducibility in observational studies of the effects of deprescribing, the REMROSE-D guidance provides recommendations for important reporting and methods considerations, including time zero, precise definitions of deprescribing, addressing confounding by indication, and careful consideration of follow-up to avoid immortal time bias.
DOI: 10.1002/pds.70255
Institutions: Brown University, University of North Carolina at Chapel Hill, The University of Sydney, Royal College of Surgeons in Ireland, Centre Hospitalier Universitaire de Limoges, Vieillissement, Fragilité, Prévention, e-Santé, Université de Limoges, Université Laval, University of Massachusetts Chan Medical School, University of Copenhagen, University of Michigan, Harvard University, Harvard Pilgrim Health Care, JSS Academy of Higher Education and Research, JSS College of Pharmacy, MIT World Peace University, University of Kentucky HealthCare, University of Kentucky
Language: English
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,650
Funders: National Science and Technology Council, Howard Hughes Medical Institute, U.S. Department of Veterans Affairs, American Heart Association, Stanford University, Duke University, City University of Hong Kong, BioMarin Pharmaceutical, Wellcome Trust, Pomona College, University of Minnesota Foundation, International Society for Pharmacoepidemiology, Duke Lemur Center, University of Alberta, Leverhulme Trust, Ministry of Education, Culture, Sports, Science and Technology, Canada Research Chairs, Fundação de Amparo à Pesquisa do Estado de São Paulo, National Natural Science Foundation of China, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Austrian Science Fund, China Postdoctoral Science Foundation, Ministero della Salute, Natural Science Foundation of Fujian Province, Shanghai Municipal Education Commission, Ministry of Business, Innovation and Employment, Korea Research Institute of Bioscience and Biotechnology, Natural Science Foundation of Hubei Province, Magyar Tudományos Akadémia, Israel Science Foundation, Krembil Foundation, Lietuvos Mokslo Taryba, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Bahir Dar University, Wuhan University, China Medical University, University of Tabriz, Shaoxing University, University Grants Commission- Nepal, Genome Alberta, Science, Technology and Innovation Commission of Shenzhen Municipality, Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, Southern University of Science and Technology, Universidad Surcolombiana, National Institutes of Health, School of Medicine, University of Alabama at Birmingham, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, Fujian Provincial Health Technology Project, School of Natural and Environmental Sciences, Newcastle University, Basic and Applied Basic Research Foundation of Guangdong Province, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, National Center for Advancing Translational Sciences, H2020 European Research Council
Awards: Prescribing Cascades among Nursing Home Residents with ADRD, Benefits and Harms of Long-term Osteoporosis Pharmacotherapy: Impact of Treatment Length, Type, Switching, and Holidays, Benefits and Harms of Antihypertensive Management Strategies for Nursing Home Residents with ADRD, Optimizing care for older adults in the new treatment era for type 2 diabetes and heart failure: Strengthening causal inference through novel approaches and evidence triangulation
OpenAlex ID: W4416208598